tag:blogger.com,1999:blog-4724592643224262209.post333648341559601436..comments2023-05-08T02:52:16.953-07:00Comments on Cognition and Evolution: Reading Comprehension and SynesthesiaMichael Catonhttp://www.blogger.com/profile/01017910055699348111noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-4724592643224262209.post-82991194330332498522014-01-03T01:32:49.419-08:002014-01-03T01:32:49.419-08:00Thanks a bunch for being a more thorough researche...Thanks a bunch for being a more thorough researcher! I'll definitely check these out. The only dyslexia-associated gene I was aware of below was (interestingly) an axon-guidance receptor, ROBO1, that supports axon growth to and across the midline. It also has a pretty exciting connection to verbal working memory:<br /><br />Galaburda AM, LoTurco J, Ramus F, Fitch RH, Rosen GD (October 2006). "From genes to behavior in developmental dyslexia". Nat. Neurosci. 9 (10): 1213–7. <br /><br />Bates TC, Luciano M, Medland SE, Montgomery GW, Wright MJ, Martin NG (January 2011). "Genetic variance in a component of the language acquisition device: ROBO1 polymorphisms associated with phonological buffer deficits". Behav. Genet. 41 (1): 50–7.Michael Catonhttps://www.blogger.com/profile/01017910055699348111noreply@blogger.comtag:blogger.com,1999:blog-4724592643224262209.post-22067224345787282812013-12-29T19:57:18.815-08:002013-12-29T19:57:18.815-08:00And a bit more digging got me this paper: http://w...And a bit more digging got me this paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668015/<br />Relevant quote: "Interesting candidate genes for neurological and psychiatric disorders and CNS development are also located in the regions of suggestive linkage. The region on chromosome 6 detected by both NPL and HLOD analyses has been strongly linked to dyslexia and specifically to difficulties in phonological decoding and orthographic processing,54,55 which is of particular interest given the importance of linguistic stimuli in synesthesia. Two genes in this region, KIAA0319 (MIM 609269)56 and DCDC2 (MIM 605755),57 have been proposed as candidate genes for dyslexia; both have been shown to play roles in neuronal migration, which has important implications for synesthesia given the evidence for altered neural architecture in the disorder"Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-4724592643224262209.post-79173274936656234522013-12-29T19:42:26.371-08:002013-12-29T19:42:26.371-08:00This is a really fascinating area of study, and si...This is a really fascinating area of study, and since I live near a research facility that does a lot of research into dyslexia, I'm highly tempted to run this by some of the researchers there.<br /><br />Anyway, I ended up perusing the ASA's recent abstracts and one of them seems to be potentially relevant to the synaesthesia-dyslexia link: Julian Ghloum1, Laura Gibson1, & Daphne Maurer - Less Perceptual Narrowing in Synaesthesia?<br />The gist of it being that synaesthetes don't seem to have undergone as much perceptual narrowing, which would plausibly lead to them having worse ability to distinguish phonemes of their native language compared to everyone else, which would then feed into any tendency towards dyslexia.Anonymousnoreply@blogger.com