Consciousness and how it got to be that way

Sunday, April 20, 2014

Treasures in the Ghettoes of Pubmed

"Werewolves and physicians experienced their closest contact in the context of early modern witch and werewolf trials."

Best opening sentence of a paper ever. From Metzger N. Battling demons with medical authority: werewolves, physicians and rationalization. History of Psychiatry 24(3) 341–355, 2013.

Discovered in the same Pubmed search: Høyersten JG. The berserkers--what was wrong with them?. Tidsskr Nor Laegeforen. 2004 Dec 16;124(24):3247-50. Surprisingly, only in Norwegian.

And a final gem, where I present to you the abstract: Psychopharmacology of lycanthropy (Davis et al 1992) (do note that there is an actual full paper behind this abstract:
OBJECTIVE: To develop pharmacotherapies for the orphan disease lycanthropy through the pursuit of the etiologic hypothesis of a genetically determined hypersecretion of endogenous lycanthropogens. DESIGN: Quadruple-blind, Rubik's Cube matrix analysis. SETTING: Community practice and malpractice. PARTICIPANTS: Subjects selected from inbred Ruficolla populations in Mississippi, Georgia, North Carolina and Minnesota. All who entered the study finished it. INTERVENTIONS: Chemical screening of blood samples over a hypothesized secretory cycle of lycanthropogen peaking on the day of maximum lunar illumination. Administration of synthetic lycanthropogens for behavioural testing. Experimental lycosomatization through the illumination method of Kirschbaum. OUTCOME MEASURES: None were post hoc, but some are still in hock. MAIN RESULTS: Two putative lycanthropogens were isolated from the blood samples. Structural elucidation and synthesis permitted animal and clinical trials; in each of these, behavioural dysfunction was observed. Antilycanthropogen strategies included application of the principle of caged compounds and generation of a therapeutic immunoglobulin. The effects of a newly developed antihirsutic agent seemed promising. An interaction of the lycanthropogen-secretion system and ethanol was noted, which may explain behavioural aspects of alcoholism. CONCLUSIONS: The incidence of lycomania in North America is underestimated. Soon-to-be-available pharmacotherapies should promote its early detection and treatment. Full control may depend upon advances in gene therapy.

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