Novartis follows several other drugmakers' footsteps; medicinal chemist Derek Lowe provides perspective, and maybe even some optimism for small companies (i.e. San Diego biotech scene).
"...there is good and bad speculation, and this is not an unparalleled activity in science...Those scientists who have no taste for this sort of speculative enterprise will just have to stay in the trenches and do without it, while the rest of us risk embarrassing mistakes and have a lot of fun." - Dan Dennett
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