Electroconvulsive Therapy and Attention-Related Connectivity
Perrin et al show that ECT reduces left frontal connectivity, specifically in Brodmann Areas 44, 45 and 46. 44 and 45 are Broca's region and 46 is implicated in attention and inhibition. Of special interest, anterior cingulotomy for refractory depression resects the same area. One interpretation of these results provides further support for the hypothesis of depressive realism and working memory (and anterior cingulate + DLPFC) hyperfunction in depression.
Left DLPFC voxels showing reduced global functional connectivity, after ECT (not adjusted for treatment outcome.)
I am a third-year medical student at UC San Diego with an interest in neuroscience. The views expressed on this blog are solely my own and not those of the university or affiliated institutions. You can reach me at email@example.com.
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