Electroconvulsive Therapy and Attention-Related Connectivity

Perrin et al show that ECT reduces left frontal connectivity, specifically in Brodmann Areas 44, 45 and 46. 44 and 45 are Broca's region and 46 is implicated in attention and inhibition. Of special interest, anterior cingulotomy for refractory depression resects the same area. One interpretation of these results provides further support for the hypothesis of depressive realism and working memory (and anterior cingulate + DLPFC) hyperfunction in depression.

Left DLPFC voxels showing reduced global functional connectivity, after ECT (not adjusted for treatment outcome.)